Protein expression services for plk4 | Serine/threonine-protein kinase PLK4
Description
Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as sass6, cenpj/cpap, ccp110, cep135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity).
Family
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
Species
Xenopus laevis
Length
944 amino acids
Sequence
MAGSIGERREDFKVLNLLGKGSFACVYRAQSINTGIDVAIKMIDKKAMQKVGMVQRVRNEVEIHCQLKHPSILELYNYFEDSNYVYLILEMCHNGEVNRYLKNRKKPFAEDEARHFMHQIVTGMLYLHSHGILHRDLTLSNLLLSSDMNIKIADFGLATQLKMPNEKHFTMCGTPNYIAPEIATRSAHGLESDVWSLGCMLYTFLVGRPPFDTDTVKNTLNKIVLADYEMPDFVSREAKDLIFQLLRKNPADRLSLSSVLDHAFMTGFSNVQSKVMGAVEDSMDSGHATISTGFTGSSGVSISGRFQEKRILSGPSLPNKVNIFQFKDKHPTERSNGGSFHNTQRENNDFSEGNGRKPVACEDRPHSRYLRRAHSSDRSGTSQSQTYAKPSSYSERCHSVEMLAKPTHLKGYRTSSPPNSYGDIPQMFTDERSLERHTSPPVKEKTPSEFMGPAKQTAPRSNDKAETVQQWFGAMQLNGQFKNTPDTSSVSNMGGDFYSQQATQNGAPQYAWNDVKRKKNTDSSIESVLLGIKKNPGTGQRKAEKSQFGEQSKSRVPQQAFGSSTLRSIISPLNAERLKPIRQKTKNAVVSILESGEVCMEFLKEQNSQERVKEVLRISCDGNLIYVYHPNEGKGFPLVDRPPSPPENRLSYTFDSLPEKYWKKYQYAAKFIKLVRSKTPKVTYYTRYAKCMLMENSPTADVEVCFYDGAKIHKTSDVIRVIEKSGRSYTLEGSRLSTLSDEVRSYLDHANESHCVCLSLESAINTEEKKGENISLFPITFGRRPALAESPKTQPTPSVDSARERKEEQSYVNRVLHGSAASPPQMPNLNPSLISYDGSVFSATTVQPSPTSNIHNTPDHAQVLKSVFVENVGWASQLNSGAVWVQFNDGSQLVVQPGVSSIIYTAPNGQITRHGENDKLPEYIKSKLQCLSSILMLFASSSSR
Mass
105.6 kDa
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service
Make plk4 using our protein expression services starting at $99 + $.30/amino acid in as fast as two weeks (includes the cost of DNA synthesis)
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