Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Belongs to the SHMT family.

422 amino acids

MLNHLKNVDPEVYSAISKEFKRQEEHLEMIASENYTSQAVMEAQGSVLTNKYAEGLPHKRYYGGCEYVDIVEDLAIERLKKLFGAEYANVQPHSGSQANQAVFFSQLQPGDTILGMRLDHGGHLTHGAKVNVSGIVFNSVQYGLNPQTELIDYDEVYRLAKEYKPKMIVAGASAYSRVIDFAKFREIADEVGALLMVDMAHYAGLIAGGVYPNPVPYAQFVTSTTHKTLRGPRGGVILCKSEYAKDIDKWVFPRLQGGPLMHVIAAKAVAFGEALTEDFKKYAEQVVKNARALAEELMAEGLRIVSGGTDSHMMLVDLRPLNVKGNQAEEALGKANITVNKNAIPFDPEKPTVTSGIRLGTAALTTRGMKENDMRRIAKNIVKVLKNLDNEKVIQEARDDVLSLCSSYPLYPDWFKDYGYGE

46.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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