Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Belongs to the SHMT family.

427 amino acids

MSDRMSLSLAQSDPDVAAAIDHEVLRQHEGLEMIASENFVSRAVLEAAGSVFTNKYAEGYPGRRYYGGCEFADVVENLARDRAKQLFGAEHANVQPHSGSQANAAAYMSIIQPGDTILGLDLAHGGHLTHGHKLNFSGKLYRVASYGVRKDTETIDYDELEAIAVREQPKMIIGGGSAYPRIFDFARMRQIADKVGAFLLVDMAHFAGLVAGGAHPSPVPHAHIVTTTTHKTLRGPRSGLILCRQEHAAAVDKSVFPGQQGGPLVHIMAAKAVAFREALQPDFSKYAQQIVDNARALAAALAGHGYRIISGGTDTHLMLIDVFAKGILGSEAEAALGKAGITVNKNAIPYDTNPPLKPSGIRIGTPALTTRGMKEAEMKQIAQWIVSALEHRNNESMLERIHGEVTEMANQFPLYGWLREDAEALAR

46.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.

Make glyA using our protein expression services starting at $99 + $.30/amino acid in as fast as two weeks (includes the cost of DNA synthesis)

Order Here