Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.

Belongs to the peptidase C48 family.

755 amino acids

MKKQRKILWRKGIHLAFSEKWNTGFGGFKKFYFHQHLCILKAKLGRPITRNRQLRHFQGGKKALQIQKTWVKDEPPCAKTKFSVDTPHASTLSSPVKRKDTKHFVSSSRTLLRLQAEKLLSSAKNSDHEYCREKNLLKTVTDFPSNSALGQANGHRPRTDPQASDFPMKFNGESQSPGESGAIVITLSNHKRKGFCYGCCRGPEHHRNGGPLIPKQFQLNRHRRIKLSPLMMYEKLSMIRFRYRILRSQHFRTKSKVCKLRKAQRSWVQKVTGDHQETLRENGEGGSGSPFPSPEPKDPSCRQQPYFPDMDSNAVVKGTNSHVPDGHTKGSPFLGKELSLDEAFPDQQNGSATHAWDQSSCASPKWECTELIHDIPLPEHHSNTMFVSETEKEIATLGQENRTSSLSDDGVKLSVSGADTSVSSVDGPVSQKAVHSENSYQMEEDGSLKQNILSSELLDHPYCKSPLEAPLVCSGLKLENQVGGGKDSQKASPVDDEQLSVCLSGFLDEVMKKYGSLVPLSEKEVLGRLKDVFNEDFSNRKPFINREITNYRARHQKCNFRIFYNKHMLDMDDLATLDGQNWLNDQVINMYGELIMDAVPDKVHFFNSFFHRQLVTKGYNGVKRWTKKVDLFKKSLLLIPIHLEVHWSLITVTLSNRIISFYDSQGIHFKFCVENIRKYLLTEAREKNRPEFLQGWQTAVTKCIPQQKNDSDCGVFVLQYCKCLALEQPFQFSQEDMPRVRKRIYKELCECRLMD

86.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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