Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting and allows the formation of distinct sensory rays. Seems to control cell-cell contact formation through two parallel pathways, one involving efn-4 and one involving plx-2 and unc-129. May also be involved in axon guidance (By similarity).

Belongs to the semaphorin family.

656 amino acids

MKAWILLLVLTRCSWGLISADNTFSDRTIGEFRELLINTKDGALFAGSEGAIFRLWAYNINDTGENVFSKKQLILSETEESECCSTASDEKLCRPSTRFLAFTNNKDSIYVCSSVGMRPEIRVLDSISLQDQQEPRTEIGICVVDPTFNSTAVVVDNGNPEDASSVYSGIRTGMGGENHLIYRPPLTKNGKQLHASIRTIYSDNKWLNEPQFVGSFDVGQHVLFFFREIAHDNSFGERIIHSRVARVCKKDIGGRNVLRQVWTSFVKARLNCSVSANFPFYFDHIQSVKRVDKHGETFFYATFSTSETAFTSSAICMFQLSSINHLLDTGLLMEETANGQFAVTADEIPAHRPGTCSSNSHSISDTDLHFAKTHLLVSDSISGGTPILPLRDHVYTQILVDQLNNQNVIFAFDSSQQKMWKISHWKEGNEWKWNLIETQTLKTSGFRINDVALLPGEFFFATSKAGVHQFSVARCQELPSCALCSMDPYCSWNAVNSKCALKTKTNEKSVGWISSSWAGRISPECSAVEKLQVKDVYLGDGFKIQGARGGTWQKDGRDLEESQRHVATSQGELVILNVDVEDAGTYECTRNGVILMRARVVVHENCARPTSVAEYRSCQREWCKKADAYKAALNIWSDSNKKNVQCKANGPSINGL

73.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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