Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways.

Belongs to the SCARA5 family.

499 amino acids

MENRAMYLTTTHEDRENSSFYEESYDGMNLSKLNLCEEVNSTKYRRKTDNRCGQLDSLTSIKYAIVSLYILVLLTIFGLCIAVSKSHASWRREEALLENVTRLGEQSETLQMSLSQIPSQSDLLENIWKLESLFHNHTEQLRLLGLLTQGLERDIKDLQAFAEHTTDSVAQLWDHLSMISHSSQRNSTHLGDELASTAGSIREQDALLKTMVGNVETLQERLEDMGWTLQTLNHSLGGDVSLHQIKIYELQEKIVNVTHDTLGMKITQTHLEDQLRNEIQVLNVVTADLRLKEWEHSMALKNLTIFQGPPGPKGEKGDVGPLGPDGIPGWIGPRGLTGEKGVQGPRGLAGRNGQDGHNGDKGEVGPEGPKGVRGERGPKGEKGERGDKQGEKVEDAVVRLVNGSGPHEGRVEVLHDLRWGTVCDDVWDIKDGDVVCRMLGFRGAKEIHKTGRFGQGTGLIWMDDVACVGTEDSIDLCKFSGWGKTNCGHVEDAGVTCNV

55.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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