Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF8, also acts as a suppressor of transcriptional readthrough.

1183 amino acids

MDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIKLYKHVVQIVEKFIKKCKPEYKVPGLYVIDSIVRQSRHQFGTDKDVFGPRFSKNITATFQYLYLCPSEDKSKIVRVLNLWQKNGVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVKISSELAQAPTNSMPTVAQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPQPQSPALDSAVMAQVQAITAQLKTAPTQPPEQKTAFDKKLLDRFDYDDEPEAVEDSKKEDAAAISTAALATAAPPAPTAATPAVATAVPVPSATSPPPPQTPFGYPGDGVQQPAYTQHQSMDQFQPRMMPIQQDTMHHQVPLPPNGQMPGFGLLSAPPPFPPMPQPGMPQPGMAQPGLAQPGMAQPTMPQPGMPQPGMPQPGMAQPGLAQPGMAQPGMPQPAMPQPAMPQPGMAQPGVSPAPPVQPTFQSTFQPQNEPHSQKPHQQEMEVEQPCVTEVKRHVPESRKSRSRSPKRRRSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQERRDREKERERRQKGLPQIKSETASVCSTTLWVGQLDKRTTQQDVASLLEEFGPIESINMIPPRGCAYIVMVHRQDAYRALQKLSRGNYKVNQKSIKIAWALNKGIKADYKQYWDVELGVTYIPWDKVKAEELESFCEGGMLDSDTLNPDWKGIPKKPDNEVAQNGGAETSHTEPVSPIPKPVPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGMPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSAKMYGSAGPPAAPTSLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPMMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGASEDRDGRQQQPQQQPPPQQQQQQQQPQQQPPQQSPSQQPAPAQQQPPQFRNDSRQQFNSGRDQERFGRRSFGSRVENDRERYGSRNDDRDNSNRERREWGRRSPDRDRHRDLEERSRRSSGHRDRDRDSRDRESRREKEENRKEKHEVADRAGGNKAVEPPLSQVGTIDTVSELNKGEAMATVVKPEESPAEVTSPVGPEKDPGSAAEPPR

129.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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