Component of the TREX-2 complex (transcription and export complex 2), a muliprotein complex that functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (PubMed:19843313).

Belongs to the SAC3 family.

1006 amino acids

MNHGGNTQAVAPMDPNSIENRYGVDGSQTQKYSYQYSTGSESAPWTGHSVENQAVENGNYSNSNYYHPQPTGPATGNVQEIPNTVSFTISSTSGTANVAQDYSGYTPYQTSSDPHNYSNTGYSNYYSGYQQQPSQSYPQPVGAYQNTGAPQPLSSFQNPGSYAGTPSYSGTYYNPADYQTAGGYQSTNYNNQTAGSYPSTNYSNQTPASNQGNYTDYTSNPYQNYTPDAANTHSSTIATTPPVHYQQNYQQWTEYYSQTEVPCAPGTEKLSTPTTSAYSQSFPVPGVTSEMPASNSQPAPSYVQPWRPETDSSHPPSQQPGAAVSTSNDTYWMHQAPSLQAHHPVPPQNNYQSPLETKPLYETPFQGHQRATYPQEMNSQSSFHQAPLGYRQPTQTAPLVDSQRVSKVQIPTNPRIASNLPSGFTKMDKDSTAASAAQAPAYVSVSMPKPKDHTTAMSDPGTFPKSLRGFVERAFARCKDDKEKESCEVALRKIVKKAKEDNTLYTRDWDTEPLSTVTTTNVTNSESSSAQLSSLQNKSPTRRPKSRWEPLVEGKPFVKPASTFSSAVKFGVWNHQNENNKKSSESFQKVDAATGFKPTYSGQNSAKKSFQRPVKRQRFSGGAATAIDDEASSDSDKDLTPYYSSAMALAGSAEEKKRRDSRSKRFEKIQGHSRGNDLTKPKNANVGNLHSRRATALRLSKVFDESGSRAVEDIDWDALTVKGTCQEIEKRYLRLTSAPDPATVRPEDVLEKALIMVQDSQKNYLFKCDQLKSIRQDLTVQRIHNHLTAKVYETHARLALEAGDLPEYNQCLSQLKTLYAEGVEGCSLEFAAYSLLYITLHSNNNRELLSSMSRLSEEDKKDEAVRHALSVRAAVTSGNYVMFFRLYKTAPNMNSCLMDLYVEKMRYKAVNFMSRSCRPTIPVSYIVQVLGFTGAASEGTDEKETDGMEDCLEWLKTHGANIITDSNGDMLLDTKATSTSLFMPEPEDAVAHGDRNLDVNDFFTRT

111.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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