Gal/GalNAc-specific agglutinin. Behaves as a type-2 ribosome-inactivating protein. Inhibits mammalian ribosomes (PubMed:10785398). The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA (Probable). The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity) (Probable). Involved in plant defense against insects (By similarity). Has very low cytotoxic activity against the human tumor cell line Molt4, but higher against CEM (PubMed:10785398).

Belongs to the ribosome-inactivating protein family. Type 2 RIP subfamily.

604 amino acids

MRVVAAILYINVVVALICGLGIQGGALDLQDYPSVSFQGDAMQLQDYPSITFNLKGATWQTYRDFIEKLREIVTRGATTIAGTSIPVLNRVVPDSRRFVYVRLINLDGNVVTIAVDVTSLYVVAFSANNNGYFFSDSTETERTNLFVGIPRGDPLGFTGNYNSLENWAGADRGSIPLGPALLNKAIRNLRSNGRDSKAAKSLIVVIQMVSEAARFRRIEEQVRRSIADQDTFTPGSLMITMEKKWSKMSQQVERSVNDQGIFTGIFTRTVQLIDDNLQTLNIDNFNALSLHTMLAILLFRCRTTTSSHNTLPAASNIVLMGEDYVDKDDEKCTVGEPTRRISGRAGWCVDVKDGRDNDGNPIQVLSCGDGQERKQQWTFHRDGTIRSKLGKCMTAYGFKHGEYVMIYDCDTAIAGANKWVVSIDGTITNPISGLVLTAPRGATGTTLLVEKNVHAARQCWRVGDDVEPIVTKIVGFQEKCLEANYLENTNVSRYTKVFLDDCVLDRQQQRWALYSDGTIRADSDRSLRVTADGHRSLDSIIILACKGWGNQRWVFNTDGTILNPNAKLVMDVKDSDVSLLQIILHQSTGKPNQKWLTVTLPRTS

67.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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