Involved in ribosome biogenesis. Seems to be required for restructuring nucleoplasmic 60S pre-ribosomal particles to make them competent for nuclear export.

Belongs to the AAA ATPase family.

837 amino acids

MVKVKSKKNSLTSSLDNKIVDLIYRLLEEKTLDRKRSLRQESQGEEGENNEGEEDEDIFESMFFAKDLTAGEIFTFCLTKDLSLQRVKKVVLQKTIDRMLKDVIESELEEFGSYPGYNNEEEEKPSLEEELAKKNMMIERDTNEMNKRITSTWSKSGSVSESITETDDPKTEEVKKSKKRSKEGTCKVKRQKIKEDRSPPNSSLKSLGGMDDVVAQLMELIGLPILHPEIFLSTGVEPPRGVLLHGPPGCGKTSIANALAGELQVPFISISAPSVVSGMSGESEKKIRDLFDEARSLAPCLVFFDEIDAITPKRDGGAQREMERRIVAQLLTSMDELTMEKTNGKPVIIIGATNRPDSLDAALRRAGRFDREICLNVPNEVSRLHILKKMSDNLKIDGAIDFAKLAKLTPGFVGADLKALVTAAGTCAIKRIFQTYANIKSTPTTATDSSEDNMEIDETANGDESSLKNTANMIDPLPLSVVQQFIRNYPEPLSGEQLSLLSIKYEDFLKALPTIQPTAKREGFATVPDVTWANVGALQRVRLELNMAIVQPIKRPELYEKVGISAPGGVLLWGPPGCGKTLLAKAVANESRANFISIKGPELLNKYVGESERSIRQVFTRARASVPCVIFFDELDALVPRRDTSLSESSSRVVNTLLTELDGLNDRRGIFVIGATNRPDMIDPAMLRPGRLDKSLFIELPNTEEKLDIIKTLTKSHGTPLSSDVDFEEIIRNEKCNNFSGADLAALVRESSVLALKRKFFQSEEIQSVLDNDLDKEFEDLSVGVSGEEIIVTMSDFRSALRKIKPSVSDKDRLKYDRLNKKMGLTEEMKDAEEMKQ

93.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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