GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with sdo1, may trigger the GTP-dependent release of tif6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating tif6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Inhibits GTPase activity of ribosome-bound EF-2 (By similarity).

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.

1000 amino acids

MPVIPPEKLVSLQKNQENIRNFTLLAHVDHGKTTLADSLLASNGIISSKLAGTVRFLDFREDEITRGITMKSSAISLFFKVISQNDEKRVEKDYLINLIDSPGHVDFSSEVSSASRLCDGAFVLVDAVEGVCSQTITVLRQAWIDRIKVILVINKMDRLITELKLSPIEAHYHLLRLVEQVNAVIGTFYTGELMQLADNDEVISDEGIYFAPEQGNVVFASAYDGWAFCLDQFSEFYEKKLGLKQKALTKCLWGDYYLDPKTKRVLQPKHLQGRRLKPMFVQFVLENLWAVYESAVSNRNLENIEKIIKALNIKVLPRDIKSKDPRNLLLAIFQQWLPLSTAILLTAIREIPSPINAQANRARKVLSSTPHYEMIDPDITLAMESCDASKEQPVLVYISKMVAFSERDLPNHRRKQLSAEEMKLIRSKLSESIESGINTISIEENVSSTNSDNLEGSTTDMDDDKDILIGFARIYSGTISVGQEVYVYGPKYDPVNPEKHITKVTVESLYLMMGQELVYLETVPAGNVFAIGGLAGTVLRTATLCSSPNGPNLVGVTQQMEPIVRVALEPVRPFEMNKLVTGLDMLNQADPCVQIAVEENGEHVIMCAGEIHLERCLKDLRERFAKIEIQASQPLVPYRETTIATPDLLAKNKELSIGFVTATLPVGGVTIGITVTPLSGSVVDFLLKHSKTIENVSSNFSKKNRNVVVSESLTKSMEEVLTPEKFYERLSKLLEEENSDLGELKNHLDSIIAFGPKRVGPNILFDKTKKMRDFRRQSDETKLIPSDLSEYVVTAFQLITHQGPLCAEPVQGICVSIDQFDISDDSEDSKLLTINNPQIPGQVISVVKESIRHGFLGWSPRLMLAMYSCDVQATSEVLGRVYGVVSKRRGRVIDEEMKEGTPFFIVKALIPVVESFGFAVEILKRTSGAAYPQLIFHGFEMLDENPFWVPTTEEELEDLGELADRENIAKRYMLNVRKRKGLLVEQKIVEKAEKQRTLKH

112.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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