S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates the pseudouridine corresponding to position 1189 (Psi1189) in S.cerevisiae 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes.

Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

267 amino acids

MSELKNGTTEPKKNETTQSDSKSKSTSTNKSSVPPASLVPVQPTALTSRDKTTQRLIVVLSQACLETYKMNSGGPGGDRFALLNCDDHQGLLRKMGRDIAEARPDITHQCLLTLLDSPINKAGRLQVYIQTARGVLIEVNPSVRIPRTFKRFSGLMVQLLHKLSIRSENSKEVLLKVIKNPITDHLPTKCRKVTLSFDAELKRVQDYVTTLDENESICVFVGAMARGKDNFADEFVDEKIGLSDYPLSASVACSKFCHGCEDVWGIY

29.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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