ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates.

Belongs to the helicase family. RAD3/XPD subfamily.

966 amino acids

MPESLIAGIPVHFPFEPYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQSEHQMQMVKMEKADFSGIGGGAPGGDLSELAKTMGRANNWGVPKVIYASRTHSQLTQAMRELKRTAYANMRSVVLGSRDQLCIHPEVMRELGNSNKTNMCKLRVHSKTCSFQMRVESRKDHPDLRGPTIMDIEDLVKVGQRLKICPYFASRELARANKIELGNTIVILDEAHNIEKICEEYASVQIKSSDVAMTIEDITHIRQVFASGESQDMAGDEPKDFTLDDLTLLKEMLLELEKAIDAVVVDNAVDGTTFPASMMYELLGKANFTYGNVASIISLLDKLVQYLLVASQQMSIRKGGTFTLLSDLLTIVFANKEDVMSKVYASFKVHVLVEESKQGHGKQQGAKQQGGWLGKGTIAAATGSSKVAKIINFWCFNPGFGMEQLLNTQVRSVILTSGTLAPLKPLIAELAIPVAQHLENPHIVDQSQVYVKIIGTGPDRQQLISNYANRDNPKYVSSLGQTILNVARIVPDGLLVFFPSYPMLNKCVDAWQASGLWADISCKKPIFLEPRSKDQFTSTMEEFYQAIRDSKGAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVILKRRYLEANRTRENQLLSGQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCDSRFKDASQVQQLSKWIRGHLGDRPQCSPFGPIVRELRQFFKNAEANMKLPDERETDSPLETVCKTEVEPLAAIPKVKREPGSNATFKSANESAIKVEMANSIKTWTPADYASAAGRKLGGAAPNAMDFMSRLDSNVSSIDFNCCTDSKSGSSGLVKIHKRERSSPTAPESTSQVSKKRYKLVENIKVEPSSSQAKVAPEDRAAFLRELRSLVTQDQFRRFGKALLEYKNGTYESFQALMAILLDVLSAPKVRYMLVGMRKYLKNEHKEEFDRRVGNL

107.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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