Essential component of the RMI complex, a complex that plays an important role in the resolution step of homologous recombination, in a process called Holliday Junction dissolution, to limit DNA crossover formation in cells. Together with TOP3A, is essential for the resolution of meiotic recombination intermediates, a step that prevents entanglement of the parental chromosomes.

Belongs to the RMI1 family.

644 amino acids

MRRRRLQLRYSSDEEEEDETGTSGVGDSVQSFGIASSIQPETSVSSNSNPNPGERIAISEVEIIDVFGNPQPTPPDSSIPTPYPVYPSESVSGNDYESPISEVLSRMGIKLKREWWVSCLSGLETSIPQFSYLDVAAKAKHCFEQFMFFDMNLCGGGVLPPNVASMNRIELAGPFVLQVDEIVNIGCPLKGRYENANAGLKRCLKLSMTDGVQRVFGMEYRPIKDLQVLAPAGLKIVVSSVQVRHGLLMLVPEIVEVLGGMVEELEEARKRLVVEVNKPPRGKRTRVGVVPSLTTRATLAAWSLNGNDTGNHVHDTGNHVNSSASGNASHTQANQGIPVHVTRTHNSSRAMDEPLASTNVGATVSRVEHMQIDTASAHGERTFSDIHSTSSNIHRAASTAGTGTSCSGACSGARSFANNVGGNSLDQTSNVTSFVEEMHIDTGRVRDTTTHIYGSDSGGVAAEFSNMVVDLEGPSVLSTNTEKPFTYLAELSQKWAVMKDTIHFVQGRIKCFLTGVKKFQFKQQSTYELLCYVDDGSLICEILLHNDVVQKRIGHSSMEVTAALSSSAPTSLNAMMKEKLKRFQLFLADFEGIMVVEMNRSSQYPVAIEMNQGCSLTDARLLLDRIKSSSRTSSSLNPVVVLSP

70 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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