Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members.

563 amino acids

MRLAQPDMVSAAPTEVDRLVWPLADGADKSPLGVLSTTEPLLRLQRTQRVWEVPELDAQYAKAFLELWPLGSFLVIGHEPGQVLMLKAGPSSGDINTYQIQRFPGGVSLESSNLCMPDCPHLLAFLSASRDVLPRTLLLPTPTVGAGDNHSDPHRLGCIQVDTSGRVLSVVNQLYLETHGGWGTETPQQTEPETGQKYSLAPRKPTPHRVSWVEDPLRPEAHHTGQEVHHPGADAHSLGSEVHFSCPALEEEEVNNDCYKDEDEEGCEDMLTAHIRALARTRSSYVARQYRCLRARLISDSGNPYSPGDPATELLQDVRQLLTDLQNYLAKDPDVRAVFGNRGPSILREEDLGPAVEVALCRAVLEPLKPALWTKLRTLRAQELRRLRRRQIALRVGAGPEGQSPALRNRNRIHARLAHLHAACAPRRKVALLLAVCSDVYAGLGGGENKEPLGADAFLPALTEELIWSPHIGETQLDVEFLMELLDPGELRGEAGYYLTTWFGALYHIAHYQPDTGRAPQGLSSEARASLRQWHRRRTLHQQAQPTAQANQPFEEPWAIGDP

62.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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