Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity). Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity). Demethylation of m6A mRNA affects mRNA processing and export (By similarity).

Belongs to the alkB family.

360 amino acids

MSATYTDLREKLQSLNRDSPKEVRKRKQPASDTEEEDEAGSEPEAEEEEARKVRSGIRQMRLFSPDECAAIESKIDEVVSRADKGLYQEHTVDRAPLRNKYFFGEGYTYGAQLQRRGPGQERLYPKGEVDEIPGWVHELVIRRLVERRIIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDSALCFGCKFQFKPIRVSEPVFFLPVRRGSVTVLSGYAADEITHCIRPQDIKERRAVVILRKTRTEAPRLEMKSLSSSYQPERLQGSNRQHILKPKRSHRKADPDAAHRPRILEMDKEENRRSVLLPKQRRRSHFSSENYWRRSHDHVDTYTETGEDEGSPVRKVKMRRH

41.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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