Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.

418 amino acids

MKFAIESISKNSGRLGQLRIKDGGPEFKTPLLLQTTKGGSIPWLSADVFETQVSRKPQVLQFTLSTMEQMTEALTHWNSGGGRGLSDYVGLPGHLNILLLRDPCETTPSGGNDRDILPLFTRRGKESLSAERYMEIVASFKPDMYEGLCDADTNLESAKKRVQKSVDRTEKFMHYIYEHRGKVNSTLLAPIVGGYNTFARTQSIKHAREQPAGSYGGYIFEGFHTNGLSATTLDTSELLPIVEHCVKQLEEDKPRILPGAYTPLTILELIQQGIDVFDTSYAYCASLNFKALTFSFVQDAVEHVPFLDITDEAIKEDFNPPLSNCNCLTCQKHTRAYLHHLYKTNELLGPILLMVHNLYHYMDFFEKIRESVAKDTLPQLTELVRNQNGKTQVDYSIAANTKVISKATMEKGFAAAAV

46.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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