Catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA and carbon dioxide. The two electrons that are generated as a result of pyruvate decarboxylation are used in the reduction of low potential ferredoxins, which provide reducing equivalents for central metabolism. Also catalyzes the reverse reaction, i.e. the synthesis of pyruvate from acetyl-CoA and carbon dioxide. Appears to function physiologically in both directions (PubMed:10878009). The oxidation of pyruvate by PFOR is required to connect glycolysis and the Wood-Ljungdahl pathway of reductive acetogenesis. The conversion of acetyl-CoA to pyruvate links the Wood-Ljungdahl pathway of autotrophic CO2 fixation to the reductive tricarboxylic acid cycle (PubMed:10878009, PubMed:29581263). Can use methyl viologen as electron carrier in vitro (PubMed:9214293, PubMed:29581263).

Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.

1171 amino acids

MPKQTLDGNTAAAHVAYAMSEVATIYPITPSSPMAEIADEWAAHGRKNIFGKTLQVAEMQSEAGAAGAVHGSLAAGALTTTFTASQGLLLMIPNMYKIAGELLPCVFHVAARALSTHALSIFGDHADVMAARQTGFAMLSSASVQEVMDLALVAHLATLKARVPFVHFFDGFRTSHEVQKIDVIEYEDMAKLVDWDAIRAFRQRALNPEHPHQRGTAQNPDIYFQSREAANPYYLATPGIVAQVMEQVAGLTGRHYHLFDYAGAPDAERVIVSMGSSCEVIEETVNYLVEKGEKVGLIKVRLFRPFSAEHFLKVLPASVKRIAVLDRTKEPGSLGEPLYEDVQTVLAEHGKNILVVGGRYGLGSKEFNPSMVKAVFDNLAATTPKNKFTVGITDDVTHTSLEIKEHIDTSPKGTFRCKFFGLGSDGTVGANKNSIKIIGDHTDMYAQGYFVYDSKKSGGVTISHLRFGKQPIQSAYLIDQADLIACHNPSYVGRYNLLEGIKPGGIFLLNSTWSAEEMDSRLPADMKRTIATKKLKFYNIDAVKIAQEIGLGSRINVIMQTAFFKIANVIPVDEAIKYIKDSIVKTYGKKGDKILNMNFAAVDRALEALEEIKYPASWADAVDEAAATVTEEPEFIQKVLRPINALKGDELPVSTFTPDGVFPVGTTKYEKRGIAVNIPQWQPENCIQCNQCSLVCPHAAIRPYLAKPADLAGAPETFVTKDAIGKEAAGLKFRIQVSPLDCTGCGNCADVCPAKVKALTMVPLEEVTAVEEANYNFAEQLPEVKVNFNPATVKGSQFRQPLLEFSGACAGCGETPYVKLVTQLFGDRMIIANATGCSSIWGGSAPACPYTVNRQGHGPAWASSLFEDNAEFGYGMALAVAKRQDELATAISKALEAPVSAAFKAACEGWLAGKDDADRSREYGDRIKALLPGEISQASGEVKDLLLDIDRQKDYLTKKSIWIIGGDGWAYDIGYGGLDHVLASGANVNVLVLDTEVYSNTGGQSSKATQTGAVARFAAGGKFTKKKDLGLMAMSYGYVYVASVAMGASHSQLMKALIEAEKYDGPSLIIAYAPCINHGINMTYSQREAKKAVEAGYWPLYRYNPQLAQEGKNPFILDYKTPTASFRDFLMGEIRYTSLKKQFPEKAEQLFAKAEADAKARLEQYKKLAEG

127.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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