Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity).

Belongs to the AB hydrolase superfamily. Lipase family.

504 amino acids

MLGRQVTMLLKVIVAVAVLFVWHRSRDSSRGDGSNGDGLSDSSGNGFRLEHIWAYDPEDVVSSCVDVSEEMRVSADEYVSMESGSEFVESWWAKTGARPFSHVFDLRSRSMDIQRLQDRDPVSMEKYIDFSLENPELARTIELEWETAKIQVPDVRNRNTVLALALMSSNAYVRTPYTGDWRNLSSSWGHTGEEKFGWDKDGLRGHIFVNKITKVVVIAIKGTSSQGLFGSGEEDTITNDKINDNLLFSCCCARISYLWTTVCDCYMKSYTCDENCVEAELKRKDRYYAATLKLYKQVTEMYPDSAIWLTGHSLGGALAALLGRTYGVPAVTFEAPGELLPAKRLHLPLPPGLPDYEEAIWHFGHNADPIFMGTCNGASSSCSIGGYAMETACHSGQYCMYDVVNDKGWRVNLLNHRIHRVIDEVILEYGRPAKCQRAPTCIDCYNWKFVNKRRNRREESSSSIASSSQLTSSHSESETLTSTDAPEKTCIGRNWLGICTDYGV

56.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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