Putative toxic component of a toxin-immunity protein module, which may function as a cellular contact-dependent growth inhibition (CDI) system. Expression of the C-terminus (residues 1519-1658) in E.coli inhibits growth but does not alter nucleoid structure. Its effect is blocked by cognate immunity protein RhsIC.

Belongs to the RHS/WapA nuclease family.

1658 amino acids

MSQDKKATLLSSEDAANQNFATDNQISGGCAKCGCEVLIHYHYDSGKPVPNAPFILIDSNKTEIHGKTDANGLCKIYDMGCGTFELMLDEGSDDFKPRETVENNPVLQSNPAYATLAGEYFTLFLLLRKQGLVTYDADDSSDRHVDVDGAGIFTSIPKEYRKSYDRFWELDKRINRGSRQLKQAINKIHHSLAAEVADKGGDDNAALMLFCEIALGFIPVVGQAMDVYSIGEWSWQSYQEPARLEDPLHIAEGALCAIGVIPGLGDALKVSGRAIIRALKVGTPKELQFAIRTIRSLSDGNLVKGLTKLRAELRNYGAQAKALLLKIHAALKQVLAESKLKNNWIVSLMKDSFSAMITSLEKLIAKYDSALAYIESKFNEFIGKVITRVSGSARPKGSIAKAAEAPKAPAHAESQAAKPATPKSDNSITKADDGKPTNAVSEKKRRTSSKETEDISAGSNKGEQPDHAPQQKKAGEEDNACKAGSDKCQGEGEPVDMATGYVVDWRTDVELTGLLPLSMKRYYRSGGERKPGLLGALWRTNWDMSLELENGIATLTDGELNQAVFVLPDEGAFSRAPSSPQWRLARQQGQLVLQHVDGLRYRFEHALGLQLCLSAIEDRAGNRIALLWDRAELCWIVLPDGRLVHVETQQRRIVKLTLCDEHRQPLKTLSSYQYDAQGHLLSVRAGEGRNFDYQYSPQGWLLRWSDLAHTWVEHEYDAAGRALRDRTAEGFWPGAFRYDDDAFTSHYHSGFGGVTTYVRDARNNILLRREPDGGEHRFEWVDNQLAAEIDPLGGRTEYQRNDWGQVTAVTLPDGSVHRYDYDDDGQLLAYTDPLGNAWHYSRNAQGLVETASDPEGRSWHHAYTTQGLLSAVNGPDGCEQRYHYNRRGLLERLEPGEAPAVTFFYDGHDRLTARHIAHEQGVQVRRWDYEGGRNTPSKVVYEDGSETRFGYDGEGNLTSVTDALGQRYLFRYGAFDNLLETTDPLGATVRYHYNAESEFAGVTNSQGQMWQYRFDTAGRLSEERHYDGRVYRYDYDVAGQLTRRTAPDGSRLEYGYDVGGRLSEIQACRADGASEGATTFTYDLSGRLLKAASPDAVVEYAYNRAGQVVSERVNGEEVRTGYDDGGQRSVVEGLLSSLSLGWQGGRLTTLSIGSHQPLTFSHTASGYEQRRSNGEGFALRHEWSATGLLSGQALDGVNGVLERRYQYDVLDCLTGITDSHWGEQAFRLNGAGQVTAERREQGRQRQARLFGYDSEQNLCEVSAIAPDGAGRLSAKNAAVQLSSGYDEAGRVTQRGGRQYQYDACGRLVSRRESRPGFRPQETRFEWDAQDRLVRVSLPDGARWRYGYDAFGRRVSKVREGQVPSAQAVARVAYRWDGDQLSGQTQYRVDGSVTRAVQWVYEPGSFRPLAQVEEQAGQTRLHYIVADLTGTARELCSETGEVHWRGEQGLWGPHREEKIPIPLRRYLGDAANEEVYCELRYQGQVYDAETGLYYNRHRYYDPELGQYISADPIGLAGGLRPQGYVHNPMEWVDPFGLVGCPLKDSPLGKNGVELERTVSKKGNVKVDTLFENSNDAKNWAAEKLGPGKTRMYDSNGKWIGWQNKTGDSVYWGHNDWGKGVGKSTYPHLNININGEKGHLFLRDKIINRGQWDDFSNAFK

184.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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