Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).

Belongs to the class II aldolase/RraA-like family.

161 amino acids

MEFTTAGLCDQFHGTHPLQIVEPLFRPFGAVSRFHGRITTLKVFEDSVLIRETLAQEVDGRVLVIDGGASHRCALLGGNLARLAADNGWQGIIVYGCVRDSVELGTVPIGIRALHTHPLDSHKRGGGDRDCLITFASVNFRTDHYLYADEDGIVVSEEKLI

17.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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