Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. Shows a higher affinity for folate than heme (By similarity).

Belongs to the major facilitator superfamily. SLC46A family.

481 amino acids

MEDSDTSAILAEDSESVDSRTVCRCFRVTENKAPPPCSCPLSVTVEPVMFLSTFSIVLQAPLCTQYLWDRLSEDVGYNGTKTGGCNASTVHDPLQTEVETLTAHWSLYINLGGFLVGLFMVILLGSWSDRAGRRLVLIIPSLGLAVQAAVYLTVMYLKLPVFWFLIGRICSGLSGDFNAILAGCFAYVADTSERGSRTFRVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFVPETVTPDPQARLFSTRHHQAVCRLYSSDAPPGRRSKLWLYILCFFLVVTVHLGCSDLYVLYELSAPLCWGPELIGYGSAAKHLAYLTSLTGLRAMQCCLEDSWVALVGLTSNMVGLVVISVADTTALMFTGYGLCFLFMASTPVLRSKLSKLVDPAEQGALFASVACVEGLCSLVSSGVFNALYPATLHFMKGFPFVFGAAILLIPAGIIGGLGCQEKRESRENREGFGIS

52.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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