Required for the production of circadian rhythms. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

Belongs to the timeless family.

single

676 amino acids

MLLRNILHIPETHAHFLMPVLQSSGGHQVSMQNTILWNLFIQSIDKLLLYLMTCPQRALWGVTMVQLIAMIYKDQHVNTLQKLLNLWFEASLSESSEDNESNTSPPKKGSGDSSPMLTSDPTSDSSDNGSNGGGSSGKKEGCDERRQALREGTEATLQEVSRKGHDYQNAMARVTADKPDISEVASDSFEVPCSPQQHLNTEEAMDDIDYEEQVQEYEQEAAAVSSEPLNLSQPANNVNYTTNAVYASTTATETQTTSSLCAMTSLCYEPFKPPAPLPTRRNTLSEMLSDNYTSHSHVSAVKLGQKSSHAGQLQLTKGKCCPQKRECPSSQSELSDCGYATQVENPESISTSSNDDDGPQGKPQHQKPPCNTKPRNKQRTLMSPQDKKELRRKKLVKRSKSSLINMKGLVQHTPTNYDISNLLKEFTVDFLLKGYNYLVEELLKQLLTSAKVLIDTSHFFWLVTFFLKLAAQLELDMEHIDSILTYDVLSYLTYEGVSLCEQLELNAQQEGSDLQPYLRRMHLVVTAIREFLQTIETYNKVSHLSEDDRLRLHQLQLQIGATTDLRCLFVLLLRRFNPRIHSKQYLQDLVVTNHILMLILDSAAKLEGGQTIGLSEHISQFATLEVMHYYGILLEDFDNNGEFVNDCIFTMMHHIGGDLGQIGVLFQPIILKTYSR

76 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.

Make tim using our protein expression services starting at $99 + $.30/amino acid in as fast as two weeks (includes the cost of DNA synthesis)

Order Here