Plays an important role in chromosome cohesion during both mitosis and meiosis (PubMed:12827206). In prophase of meiosis, it is involved in the formation of the synaptonemal complex (SC) and specifically, in the diplotene and diakinesis phases of prophase, it stabilizes the association of homologous chromosomes during synapsis and sister chromatid cohesion (PubMed:12827206). It regulates cohesin subunits to promote meiotic chromosome cohesion and localizes non-SMC (structural maintenance of chromosome) cohesin subunits to chromatin prior to or during pre-meiotic S phase (PubMed:12827206). Implicated in influencing either the stability or loading of meiotic-specific cohesin subunit, rec8 (PubMed:12827206). Controls cell cycle exit and cell fusion to prevent the premature differentiation into adult cells (PubMed:15691769). Specifically, regulates hypodermal seam cell identity (PubMed:15691769).

Belongs to the timeless family.

1353 amino acids

MNVLVQGAVHALGYYEDGKYSREPDCYESIRDLIRYLREDGDDHTARIECGRHNLVEQDLVPMVKCEDLTDDEFDIAIRLMVNLCQPAISTMRGKPPADRDQWKMYWELEENLRRAKTAFSDAHFFTAIKKRIDNYFIDTEYEDRDERLRLVVERIVLLIKYVFSINPDTSEGRRTRIEDSSHDRVIIAFLESGIDKTLMHIANQPREKEFHVTILDIFALILKEQTAEDLATKSEEVSTAEQKKTEEEFRKIIENHVVKETQKRKSFSRFGGSYTIKGLKGISANSSQVVFKPIQNVEKHNFLDDRKAKKRAPRNRRPFEIDTNSHFASSEVRGMLRDMVIRIIETCFNRLMKSSKTTVFVQVQKTSQINYFFLIKFVLRFVRLSRQDHLLERISECIGVEAFHENNVQLTEYVENATTLKGVEAKSHGLKAQYALGAYNELVLLHRYIYEHAKEENERKFAKRALEHIVNVEEYRELPIFIIKKFSSSVLSNNFLRELVLTTHHYMKLVERFVKTGALKKVTKKVKVRKATKKSKMSEEDVRSEFDGMSKKDLDRLWEESKGLVLQILKKEVPEMRGMNPIDSQLDVPVDAQQKFAKLSIQRSLRSRGFPAAVGLYHASRALWPESFKRGLTDFQDSPGEEDQLQELEQLLKADMKKVAKDLKKAESCKTCDEDPAYKKYDKMDATALQSLWEQSTDTLARILSHELPESESTSPVNWQLDITPDVQQKFAMLAIQRALRARDLPAAVGLYHTSRKLWPGDEAIFGAPGIGVEEEIAELKAILEADLHEVAREMKVAEDRAEDPDEEDPAEPYDSEQEEEEEVPAWKVEEIDFQFDSYVCKFSNVDVLKWYVFLLNDFSKNSTELNQALVKMLHRIAFDLKLPIKLYQVSLFQVFSKVNEHFTHLSKDLRKSSRLYELYQFGFHLLKKFFSKFTGDLAIEALFWKGPRECFEIENGYGSWVKSREADIRVWTEDLEIELRNLYEEYRTMETRDGIDVLDFIEHNLSRARSRKKVAKKLIEFGFDLLGAKWKNSDKARMDSVLPIGDIQKWYDEWKEAGARGDLVNVLQEKLNEDLGMEISRKKILKQLAHMDILYEKPKKEKPLPQWDTGLIEELKKLKEQYDDIPDALNMLGVNIVRYVMKRLSEKKPTRQVERHLESLGATIPERSKKSEKNGKKFDDFLNDDDDDSENDVGGGSEDDEEEEIVMKSKRIIPDSEDEEEHIEQEEAQKKLEKVAEKPNTLMGMIAGRKRKLAQLESDSSDESDDDDSAEKEEKKLPAAEDDSDLEEDAVIYKRSYVDALLTGGSIAGNGITETRRDTSEEREDDDDEDPFTKKLTFKRRIVMSDNEDEA

157 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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