Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity).

Belongs to the shisa family. SHISA9 subfamily.

393 amino acids

MKSTGLLLGYFLMKVLVCDAEGEPGKSLDGAVTASGSNDSRDGENGLSETPHTEDRCRGYYDVMGQWDPPFVCRTGSYLYCCGTCGFRFCCEFKNSRLDQTTCKNYDTPPWSMTGRPPPKMMDQHDPTKDKTNLIVYIICGVVAIMALVGIFTKLGLEKAHRPHRENMSRALAQVMRQTAPGEHVEREESLAVHGQPYENLQARATGNNLQSAQMNSVGPSSSMMQAMTPYPALGQVPVAHPYEPSPAAKELNKYASLKAVAEKANENFYTNRRHLADLAAKGTLPMHSVSLEQEPTNPYSPELPCQKQNGHKSKSTKVHSSHPLAYGSNTIANPGRMSSWETTETLGRRHTYGPKKHSATMEQMNELTSAQSQHYLPPHPYFVTNSKTEVTV

43.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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