Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase gpi14 (By similarity).

Belongs to the PIGX family.

543 amino acids

MRRRITFVQRPETPFSLDQAVLTPDALALHGIDGAREERATFSVDELPEELSDVLKQCHQLHVRWASERRYDAVAPFSSRVSPGLHVFYTPVDGSSEENKLKSLCALLKRAFDYGLKCKSPETLEESFITPPILSTRFASTAAFQYHSLLPTLDNLVAYIENKICSSSDEQCLRYAASIRSADSVDINYDSISHSLTVLGYWSQSPKNGWTDEIRRHAAGTDQVEVGLLGTEAATEPEDIKMGGLLAVVGKDDQLSMLSSGLPSEFGVAYGYGTDDSWAEPTLFSFPSRHQPLPEDATYSISFTSPTGLHPTMTISMPPSSLNSPPAPPDATCALHTYLTLPSTIFGDKYQLSTTDPLFLDSHNLVALHAVAGETDLEAPDWFVSRWGSNWLLELATPSESDQVPEEWNVTIPLHLRYLRPSESGYRSASVPWPVVFWACTAEDGTKMGVNPFDRVNLGWEGLFGTRTMFYQLHPSSDRLVEELEVPVLQLDDKGFFQSKAIELGTMIVIGLGSLWVLWKLGAIAWSSGTRPQRKSTKQKKSE

60.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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