Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for neuroblast specification (By similarity).

Belongs to the NKD family.

1009 amino acids

MAGNIVKWWKHKILGGYKQFSVQECTTDSEELMYHQVRASSSCSAPPDLLLVSERDNNIQLRSPVVNIITTPPGNASGSASNKQQQLQQQQGHQHHHQAMPMPHTHASRHHHHQQQQQQQLPQDMSSSGSHTKHLRISSSSGGKHGKYANMQQQQQQQQTAAAATGVDEDVVDAAAAAAAAPHGAHQQMHSRHLHHHKEERIRLEEFTCDVSVEGGKSSQPLQFSFTFYDLDGHHGKITKDDIVGIVYTIYESIGKSVVVPHCGSKTINVRLTVSPEGKSKSAQQPAMAMGVVPASVPLPAAALGNNNNSNNNNNNKLKKLPTGLAAMSKQMNGGNGGGGALTTSAGTRRQHRYRPRKLIKSDDEDDDSNSEKEKERERERERESHAADQQPSGSGSKGAGSKSHHHHHHHGRYQKNQSGAKLEHQQQQQQQLCCADTPDNTYENMLNLKQDTQAAGNEATVPDCPSSHRQLHHQRQQDIYMKQATQRVKMLRRARKQKYQDHCLETRQRSLSVGNDSGNWQNRHLQQSLQQQPQAAHKSASVSPPPLAGELMLDGVQLRQPRPPHQSHHQQLQQQQQQRKSAECWKSALNRNDLISIIRESMEKNRLCFQLNGKPQANVSPIRQPAAQQQQQQQRQRSSTGSKIPTLIANHSPAAPQSPLSCSPPPCTLSLSLSSSNHPAAATCSIPVPAQAQAQGQAQAQAQVPAPPAVIEVGGGHHQHDHPQPHIPIYHQQLAINPAVLAAQHSHNSAHNKLNLCGYDSFLHATICGGGSAAHSPPPTPSNVATVQPIPKKSHNQKSLLQGYQRLEQQQQQRSSKDYKNYGNLIYAKLSEQLQQKEREQRRHRHKQQQQQHHHQQQQQQQQQQNQQQQQQQQPLKPKEESLAEQRPPTSSSSSAGSKIFGDALECAHLLASEEEDLPASPPLTHSTPSKVVSTDTLIDLNDDVGEAVAEAVTESGGKQQQQQALEADEGQEQEVELDTSASSSMIHRYVHEHIHHHYHHFKEQQDV

111.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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