Essential arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins SmD1 and SmD3 (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.

690 amino acids

MSCFSHVMNPITGQNSWQERGDDYDYHLEVANAGFGDMLHDWERNQKYFAALKKTIAGMREAGREVHVLDIGTGTGILSMMAVEAGADSVTACEAFLPMANCAERILAANGAGDKVRLIRKRSTEIQVGEDMPRKANLLVAELLDTELIGEGAIGIYNHAHAELLTEDALCIPARARCYAQVAQSPLAAQWNSLKTIANLDGEPLLHPPEQLKSCQGEAALHDVQLSQLPSSAFRPLTDPVEIFQFDFQRKLEREKQRAQLLTLQSKQPGAAELVFYWWDIQLDDGGEILLSCAPYWAHPQLKELAAEKGKDHPLANVLPWRDHWMQAIYYIPKPLQLVEAGKSFHLSCHHDEYSLWFDAREEAPTKSVRRHTCTCDLHMTYSRSRIGQINQSTRNKRYLRYLEENIEAEKSNVLVLGNGCLLGLASSALGAASVLLHEPHRFSRRLLESIVTHNQLKNVQFLDKVEELEDSQLSALTHVFAEPYFLNAILPWDNFYFGTLLTKIKDRLPESVKISPCSARIYALPVEFLDLHKIRAPVGSCEGFDLRLFDEMVERSAEQAVSLVEAQPLWEYPCRALSEPQEVLNVEFSSFTQEHSLKGSIELKHPGTCNGVALWVDWQLVEENSPRSIVSSGPSEPVVPGEFVKWDMFVRQGVHFPRRPTGGITHLEWSTDFKPVLGELNFSFGQKKL

77.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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