As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homologue pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation.

525 amino acids

MDMPEDQAGGPTAKMYLWDQAEDRSLGTLLSLEEQILNSTFEACDPQRTGTVAVTHLLAYLEAVTGRGPQDARLQTLACSLDPSGEGPQATVDLDTFLVVMRDWITACQLDGGLELEEETAFEGALTSQQLPSGCPEVEDPANLESFGGEDPRPELPATADLLSSLEDLELSNRRLAGENAKLQRSVETAEEGSARLGEEISALRKQLRSTQQALQLARGVDEELEDLKTLAKSLEEQNRSLLAQARHTEKEQQRLVAEMETLQEENGKLLAERDGVKRRSEELASEKDILKRQLYECEHLICQRDAILSERTRHAESLTKTLEEYRATTQELRLEISHLEEQLSQTQEGLDELSEGAQVRRVDCTNLLPPSLGVELQAIQQRNLQEESAHPQEGREEPSTRLPRREEEDGAEIQVMVDLPLHPEDSHPGDILGNPPESSPSEPELQQALVPMVKELVPVRRPVWGQLCLWPLHLRRLRVTRHLLIPAPLLGLLLLLLLSVLLLGQSPPPTWPHLQLCYLQPPPV

58.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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