Description
Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
Family
Belongs to the methylthiotransferase family. CDKAL1 subfamily.
Species
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Sequence
MVKVYIENYGCARNRADGEIMAALLYLSGHEIVESPEESEIVVVNSCAVKDPTERKIARRIRELLDNGKKVIVTGCLPHVNPDVIDERVSAILGVKSIDRIVQAVEYAMRGEKLISVPDWKKRNLDKLDFPRLSPRNVYFILPIAEGCLNACTYCATRLARGVLKSYSPEKIIGWVKWAIKQGYKEIWLSAEDTGCYGFDIGTNLAKLIDEITAIEGEFRIRVGMMNPNHVLKFLDELIDAYKDEKVYKFLHLPVQSGDNEILRKMGRMYTVEEFEEIVKAFRREFPELNLHTDIIVGFPGESEEAFQRSVELIKRIRPDKVNVSRYSPRPGTIAAKWKQLPGWVVKERSRLLHRIRLQISYEINRKYIGKKVKVLIHGEGKKGNVDAVTMNYKHIILPEGRKGEFREARVKNAASTYLLGEIIT
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service