May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9 (By similarity).

Belongs to the methyltransferase superfamily.

453 amino acids

MDHAAAQLEKQHVHDVYESTAPYFSDLQSKAWPRVRQFLQEQKPGSLIADIGCGTGKYLKVNSQVHTLGCDYCAPLVEIARSRGCEVMVCDNLNLPFRDQGFDAIISIGVIHHFSTKQRRIRAIKEMARVLVPGGQLMIYVWAMEQKNRHFEKQDVLVPWNKALCSQRLSESGQPGRKQECGHPERGYPYHPACSACHCSVCFEGRCNSKRSHSVDCDSVLAGTCCANISKEGEEENGFYNTLGKSFRSWFSSRSLDESTLRKQIEKVRPLKSTESWANSAISIQPSRHSSFDLGHPETLSAGEQNLDEEVFVEPSQGPREWLRAPTTCKQLNGDHPGVIRRNGDGNFLGGANAKESCVDEGNLEEGTASGSKLWRRISAADSTDSNPGDAISVEEQQPDVLDSRAFMRYYHVFREGELCGLLKESVSELHILSSGNDHGNWCVIAEKRESCD

50.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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