Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.

Belongs to the NDC80/HEC1 family.

736 amino acids

MSQDTGLFSIKRPRESLAHFSALPQPSSALKRTSSIGAFGNPPTAQHTRMSLLNSASRPQQPNFQRSSSGGAFGADAGLSSVRRSVSSNIFHGASAGRQSYAPGSFSSNPASQNLQRRSSVFSRPSAGVGGAMGHQSFFTQVPNAAGVPRDPRPLRDRSFQARIGQELLEYLTHNNFELEMKHTLGQNTLRSPTQKDFNYIFQWLYHRIDPGYRFQKSMDAEVPPILKQLRYPYEKGITKSQIAAVGGQNWPTFLGMLHWLMQLAQMMDRFIMGEYDEACAEAGVDVSGDRIIFRFLTGAYHDWLQGGEDEDDETAGQRLVPHIEMMAQEFERGNEKYVQEVQALEAENRALRDQIEEMEKSAPDMAKLDKHFRILEDDKRKFEDYNQNVQGKIEKYENRIKFLEDELQKTEADLQAAEDERAGLQSSVDRQGITIQDIDRMNTERDRLQKILDDTMGRLEETHSRVMEKEKEASEKLEALEEVVKAYNTLGYQTSLIPSSAVNAKGQDYELSLNVNESNFSASQIGSAPSRISPEGDRLLAEPFTGYHPAHLLSLDLRGTVRSSLQTLRKDINERRKRAADDDLDRRNLLDNIKEAMDEKRSEVEALEHRRRAAEEEFERTKEITTTQKLASDAQIEKMEKELAKMRATMSESVQLMEQREMNTNIEYEQLTLRANALREELHTNVESMLNDVIRFKVHVQKGLEDYEGFVVDEVEQELGGDMVPADDIPPEEEL

83.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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