Toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. This protein may be a nuclease that is specifically inhibited by its cognate immunity protein RhsBI. Upon expression of the C-terminus (residues 1284-1436) in E.coli growth is inhibited, cells elongate, nucleoids condense and plasmid DNA is degraded; these effects are blocked specifically by cognate immunity protein RshIB. Cell contact is necessary for growth inhibition.

Belongs to the RHS/WapA nuclease family.

1436 amino acids

MLNDILSRVARVGAMHAGNRPNPPADRPQPCQGKPPTSPGKTIKHKSFLGALAGAVAGALVAAAVAAAAVFLVGVTGGLAVAAVGALAVFAAGDLISAVTNKVSAVVDSASPAFGPVASGSGNVFVEKQPVARATKDTVACTKHNSPQLIAQGSESVFVNDAPAARIDDKTVCGATLKEGASTVFFGSGQGTYLEIADEFSWWEKALLIAVEFLVPPSRGMLKGLGKLFTRNGLKSVLKGAKAGALFITKVPGKMGCAARAFKANKGMARFKEAAKAFKKDPVYLASGEVIESRTDIELGQTLPLVFERTYRSASAHTGLLGRGWHDSWSEVATVTHDGLNTHVVITLAQGYDIDFTFHQDVQAVYCPHYPEFTLHRRGDGFSLWHRDQQTWRDFSVVQGERRLLSAIHDSHDNRIELVRDPKGYLRQLRHSDGVTLLLVWQGEYLHQIQRIDGGQKTLLAEYRQDEQGRLVEANATHAYHLYYEYNTAHRLTRWHDNDQTWARYEYDAQGRCVYTTCADGFLTARFDYLPDRVVMTDGLGQRSEFGFNDLHLMSWEQSPLGHITRYEYDEVGNLLREISPAGRVVEFTYLDDTGRVSTFTDGSGHQWQYDYDDAQRLCGVTDPLGREWGWVYDAEGNPERLTGPDASEVRFTWNRYGLLTQVSDAAGEVQARLQYDHRQRLLSATDAESRTRQLRYDRQDRVVQWQRADGARFRLGYRRASWTLPEQLIRPDDKEEQRQYDRHNNLLSYVDGNGALWRQTFGPFDLLTARTDAEGRTWRYEYDRESQQLIAVTAPDGSRWQWWLDADGRVIRERDMTGTETHYGYDEDGLCIRVRNGEGDTRHFLYDARGLLLRETAPDDTLHYRYDAAGRLTEVSSATAHVQLDYDLRDRVVREWHNGTLLTRQYDDAARTVTRTLTWDGDADDTTGTLAPLTSLFHYTRTGELRQVQLPDGADLTLTHDAAGRESLRTGGSGFVQQREYDVMGWLTREQSGAQHDGRLQPAQTREYRYDGAGNLTGVRHNRDAEGYRLDATGRVQEMLSGGAGKPVDTTARFHYTRTGLPQEAGRLTEWQAGRLVQHDDTHYQYDRAGRLIRKQVVQPGYRPQVWQYRWDSRNQLRVVDTPNGERWLYRYDPFGRRVGKRCDQKAEETRYLWDGDQIAEIRHYRHGQLIQRRHWVYNGWELVVQQRQHTGGDWETDFVTSSQNGTPQALFTPDGTLRWQVPKATLWGQRQTEKSESPDPGLAFAGQLRDSESGLCYNRFRYYDPAGGCYVSPDPIGIAGGESNYGYVQNPNTRVDPLGLAGCAMGEILADADKWSLAKIGDRQKGMIKDKLSTVKERSKALNTKMREHFNANEQKIISEWEKQTGMNWPTLSSGSRATPHHVIPIKNGGSNEWWNIIPVQHPHTGTIHGTGSALRTHLPYQKDGGKLWNLLGY

161.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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