Possesses intrinsic ATP-dependent nucleosome-remodeling activity. Constitutes the catalytic subunit of several complexes capable of forming ordered nucleosome arrays on chromatin in vitro (By similarity).

Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.

1107 amino acids

MAKPVKYDEEEEEVSSSGEEEEEQSDGAGSGSGEEEDEEEEEAPAAAAGEAAGGEEEEVDEEEIEAVTTGAGADEEEEESGAAAAAPGEGDEESQSTEDDEAVVGEDDDADEAEGGAVVGKREKARLKEMQKLKKQKIQEILDTQNAAVDADMNNKGKGRLKYLLQQTEIFAHFAKGNQSKEKKPRGRGRHASKMTEEEEDEEYLKEEEDALAGSGGTRLLSQPSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEFRGITGPHMVVAPKSTLGNWIKEIQRFCPILRAVKFLGNPEERNHIRENLLQPGKFDVCVTSFEMAIKEKTTLKRFSWRYIIIDEAHRIKNENSLLSKTMRIYNTNYRLLITGTPLQNNLHELWSLLNFLLPEIFSSAETFDEWFQISGENDQQEVVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYRALLQKDLEVINAGGERKRLLNIAMQLRKCCNHPYLFQGAEPGPPYTTGEHLVENAGKMVLLDKLLPKLKDRDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIEAFNKPGSEKFVFLLSTRAGGLGINLATADVVVLYDSDWNPQADLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQGRLAEQKTVNKDDLLQMVRFGAEMVFSSKDSTITDEDIDRIIAKGEETTAELDAKMKKFTEDAIKFKMDDTAELYDFDDDKEENKLDFKKLVSDNWIEPPRRERKRNYSESEYFKQALRQGAPAKPREPRIPRMPHLHDFQFFNNQRLNELYEKEVRYLMQANQKKDTIDGEDEDQLEPLTAEEQEEKEQLLEEGFATWTRRDFNTFIRACEKYGRNDIRSIAAEMEGKTEEEVQRYAKVFKERYKELSDYDRIIKNIERGEARISRKDEIMRAIGKKLDRYKNPWLELKIQYGQNKGKFYNEECDRFMLCMVHKLGYGNWDELKAAFRMSPLFRFDWFVKSRTTQELARRCDTLIRLVEKENQEYDEQERQARKDKRMAKNMTPTKRSALRVSEGETTPSNSFKRRRQSLMDDYVGSGRRKRG

127.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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