Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity.

Belongs to the WD repeat PRP19 family.

505 amino acids

MALICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPVNNQPLSEEQLIDIKVAHPIRPRPPSATSIPAILKALQDEWDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIARLTKEVTAAREALATLKPQAGLIVPQAVPSSQPNVAGAGESMDLGELAGMTPEIIQKPQDKATVLTTERKKRGKTVPEELVEARGAQQVPGRSPRMWGLHSASIPGILALDLCPSDTNKILTGGADKNVIVFDKSSEQILATLKGHSKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHEGSVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDESSGCALTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL

55.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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