Protein expression services for kcc-3 | Potassium/chloride cotransporter 3
Description
Probable potassium/chloride cotransporter that functions in the amphid sheath glial cells to regulate thermotaxis behavior (PubMed:26463820, PubMed:27062922). By maintaining chloride homeostasis, negatively regulates guanylate cyclase gcy-8 in the thermosensory AFD neurons and thereby controls the microvilli receptive ending morphology of the AFD neurons and thermotaxis (PubMed:27062922). Modulates the temperature-evoked neuronal activity of the AFD neurons such as calcium responses to temperature gradients (PubMed:26463820). Might also play a role in the chemotaxis behavior mediated by the sensory neurons AWA and AWC (PubMed:26463820).
Species
Caenorhabditis elegans
Length
1070 amino acids
Sequence
MSNARRRFSTVTQINTEGLQAMGKGGGRMETVGEDGIPADYKGNRKFTTSLGHLALYKEDEGIGTQASFISGYTTPGPKERATSEHVKANLGVMLGVYLPTIQHILGVTMFIRLFWVVGMSGVAWTMALLAICCLSTLLTSISLSAVATNGVVESGGAYFIISRNLGAEFGSAVGILFYLANTVAASMYIVGGVEVILMYLWPEMAIGGADALHDTEMFGSLYNNLRLYGTVFLLIQALIVAMGVKFVQLLAPVSLMCVILAIAACIGGGIEKQITMEGMKVCAIDNHLLQSSIVTHPIHKNQTSWFNETVDFCNLCDKSLYLESVFCANVNNDEASAEDDVFCTHYTSKKMTCQLAFPGFNMKTLNDNMWPEYMEKSEVVPGVRGKETAEVVQDESSTFFMLMAIYFPAVTGIFTGTNMSGDLRDPQRSIPVGTIAATLTTSAIYYILAILFGGSITRSVLRDKFGRSIGNTMVVAALSWPHPAVVTVGAFLSTFGAALQCLCSAPRLLQSIAKDDVIPILAPFARVTKNNEPFLGLVLTVIIAECGILLGAVDKIAEVLDFFFLMCYAFVNLIAVLHSVLKSPNWRPRFKYFHWTLSLLGAALCFFIMFASSVPLACIACTATAVIYKYVEWKGAKKEWGDGMRGLALTTAQYSLLKVEDKDPHPKNWRPQVLILLTSQWSKEMIDRRAVSMLNLGAQLKAGRGLAIACAFLKGSVDSQKDKNRARDVKTTLVKDMSSVRLRGFAKTMFYNNHQINGTISGLYQSIGIGGLRPNTILLNWPNEKNPDELVLFAEEIIHGAANDNCLIVTKGITDFPEYSERLTGFIDIWWIVQDGGILMLIAYLLRQHKVWKGCTLRIFAVSEQDSTKSEDMKAGLQKYIYMLRIDAELFIVDLLDMEVSDEVVEKAAEVERKQKEREEMRRSKSGYLNDGFMEDNGKPRQVMMRHSDSARSFSPQPGAHTSINLDETETSFTESLFDDFYRSGTPNEDLEGAMKLNIHKMNTSVRLNRVIRENSPDSQLILLNLPSPPRNRLAFNNSYMTYLDVLTEDLPRVLFIGGSGREVITIDS
Mass
118.2 kDa
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)Safety
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Protein synthesis service
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