Uses inorganic polyphosphate (polyP) as a donor to convert AMP to ADP. Can also use GMP, UMP, CMP, TMP or deoxyribonucleoside monophosphates, with lower efficiency. Cannot use low-molecular weight polyP as donors. Can also catalyze the synthesis of polyP from ADP or GDP, with lower efficiency.

Belongs to the polyphosphate kinase 2 (PPK2) family. Class II subfamily.

475 amino acids

MDTETIASAVLNEEQLSLDLIEAQYALMNTRDQSNAKSLVILVSGIELAGKGEAVKQLREWVDPRFLYVKADPPHLFNLKQPFWQPYTRFVPAEGQIMVWFGNWYGDLLATAMHASKPLDDTLFDEYVSNMRAFEQDLKNNNVDVLKVWFDLSWKSLQKRLDDMDPSEVHWHKLHGLDWRNKKQYDTLQKLRTRFTDDWQIIDGEDEDLRNHNFAQAILTALRHCPEHEKKAALKWQQAPIPDILTQFEVPQAEDANYKSELKKLTKQVADAMRCDDRKVVIAFEGMDAAGKGGAIKRIVKKLDPREYEIHTIAAPEKYELRRPYLWRFWSKLQSDDITIFDRTWYGRVLVERVEGFATEVEWQRAYAEINRFEKNLSSSQTVLIKFWLAIDKDEQAARFKARESTPHKRFKITEEDWRNRDKWDDYLKAAADMFAHTDTSYAPWYIISTNDKQQARIEVLRAILKQLKADRDTD

55.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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