Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward EA2 peptide substrate and a much lower activity with EPO-T, Muc2, Muc1a, Muc1b.

Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.

578 amino acids

MAVRWTWAGKSCLLLALLTLAYILVEFSVSTLYASPGAGGARELGPRRLPDLDTREEDLSQPLYIKPPADSHALGEWGRASKLQLNEGELKQQEELIERYAINIYLSDRISLHRHIEDKRMYECKAKKFHYRSLPTTSVIIAFYNEAWSTLLRTIHSVLETSPAVLLKEIILVDDLSDRIYLKAQLETYISNLERVRLIRTNKREGLVRARLIGATFATGDVLTFLDCHCECNTGWLEPLLERISRDETAIVCPVIDTIDWNTFEFYMQTGEPMIGGFDWRLTFQWHSVPKHERDRRTSRIDPIRSPTMAGGLFAVSKKYFQYLGTYDTGMEVWGGENLELSFRVWQCGGKLEIHPCSHVGHVFPKRAPYARPNFLQNTARAAEVWMDEYKEHFYNRNPPARKEAYGDLSERKLLRERLKCKSFDWYLKNVFSNLHVPEDRPGWHGAIRSMGISSECLDYNAPDNNPTGANLSLFGCHGQGGNQFFEYTSNKEIRFNSVTELCAEVPQQKDYVGMQNCPKDGLPVPVNIIWHFKEDGTIFHPHTRLCLSAYRTAEGRPSVHMKTCDALDKNQLWRFEK

66.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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