Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity).

722 amino acids

MDFISENTISDKTTLEELKNATLFQVTKVDDRDCLRARRICNAPKGHWAGLMEKAKAMGDPTEEEKDELKKIVESYNTVSVLGVSKSEGATGPRLVSSLKGLKNLLPGVNPKTLQETLLVGAPCPSTEPTTEEYWNVCRAAVGASMGSAKINMSQKVVMGASVIGWGQLNQSGPGVYFLNTKEIVTAEGKVDETRGPLERTSAPLMRDISRLIQETIEEVETGGDPSFSVRSEGGSKIEGRIAFSLHSEVSTLKMRIALEQKLAKYEYMGENLLTLVKNTSIDRMQPDSAMMGKMVLESLRTHTVSSEQLNGRMITVQSQGLETIAISSPFDVEYDDGYVFTRMKGNFVAVGRDYKGAILCFREGQGTFFSGRGNWSGLMEKCLVEMRLCPCFYSCTWQDYPDKKSLYEKATFEAKQIVFAMGENTGVDIRVNTDGEIGDKGISLLTREREDKYMSKVSYECRVVSGKLVMGLDKMSRVAKGNLEVVREKGDDTSQSDSFYEGVLQVGSMIGTTMESLKQQLQGPVGIWRASGVSAMERCMKRGQSKTVVASARYTFQKMMEKMATGREVSKYSLIIVMRCCIGFTSEANKRALTNISGTGYYISVAQPTVVKLAGEWLITPVGRSKTGEVQYVSAKLKKGMTTGKLELIKKADRSDLDNFPEPSADELLREGTIVLMQIGKDKWLCRVRTGDRRVRTDTDIQRAEAKSQVEKEDLMDEYGV

79.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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