Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (BX-C) complexes, and hence for the maintenance of segmental determination.

1601 amino acids

MMTPESKAIQPAAATTKQTAEATATTTMAHTQQKSQLSTLAKTTTTTATNKAAKSVVSNANSSGNNSSKKLALSQSQKTTTTTTPPTTTTTTTAAAAAEATTNADKMQKQQQLKQQLFAACSIKVKSENTLATTANAALAAATTTTTTATPALATGKAAKTILENGIKKESTPPAVESVEASSSSSSSSSSSSSSSSSWPTTRRATSEDASSNGGASADEEKSEEDPTAAVAASSTATTTSDLATTSRPRPVLLTAVNPHIICHLCQGYLINATTIVECLHSFCHSCLINHLRKERFCPRCEMVINNAKPNIKSDTTLQAIVYKLVPGLYERELMRKRAFYKDRPEEAALATPEQRGDDTEHLIFSPSDDMSLSLEYAELGELKTDSEPELVDTLRPRYLQCPAMCRVSHLKKFVYDKFEIDAQRFSIDIMYKVKTIVLLDYYTLMDIAYIYTWKRDAPMRFYYRVYESPQPLVKPAPRRVLPLKLEKQERENQEQQLAVEVASSKVEPVSLPEDQKAEASIKVEEQESTREIVKEVIKDVAATPPTETLKLVINRNMLDKREKSHSPQMSSKSSSKSSPCTPVSSPSEPNIKLKIDLSKQNSVTIIDMSDPERREIVKPLKPEKESRSKKKDKDGSPKSSSSSSSSSSGERKRKSPSPLTVPPLTIRTERIMSPSGVSTLSPRVTSGAFSEDPKSEFLKSFALKPIKVKVESPERTLNNRAITPPSPSVQQSASPKSKGNNLDDSILMKPPSCMPPKSIASSKRKSKEPVKAVSKKQKLSPPLPTVDFKIRLPVTNGNSSGTASPKIEKPLMPPPAKPPMLAPRKLQPSAQFAPPPSPIHHHAGVQMSAPGNRTPIAKRYQPILPKASRPNPFANIPNDVNRLLKDAGTEIKSIGGGSVENNSNAAQKPHLYGPKGESKMGPPALPATTPSQGNKNVGKQAGNLPMSAPPNKGNSSNNYLNLALFNSSKCKGKEAPPGCRTPMYTPNSPIYSPSSPQYVPSYNIPTMPTYKYTPKPTPNSGSGNGGSGSYLQNMLGGGNGGSLGGLFPSPPTKSDQNTNPAQGGGGSSSATQSGGNNGIVNNNIYMPNEDAPEKQQVKVKSLLNSCNINIPSSLSITISRDNGDSSSPNNGQHPKHKSPVNNYIEIVKLPDQPQDQVQAAKEAQKRQSPPAAVPGHLAAKLPPPPPSKAIPSPQHLVSRMTPPQLPKVATPPPPSSPRVITPPKTSPPANAAKVTPLKPVLTPTQVDKKTPSPEKRTAAQMGSHSPTASENKSPKGGPAGVANSTGGAQNGDPAAKKFRPILPRQNGMPELAPKLPTLAPFVGFNPLQNPAAGKKVPPSKKSPNAGAAAHQSGQQKLVNGGQSQPAQQKTSPPAQKNQQQVKKVSKNPTPPPPSLPAVGKMMPHPVMHSQNAPLSIASSASAAAVASGQLDLSNFLKENLRRVHAAQAAQAAQVAAAANQSNMMYNLAQMGHMTPAMYNYQQAYFREQLSRMQRVGNEVFNDYLQKLKTAAATGGGGPVEGELKPMLPTVTLPSPGATPPAASPKTSPLPAGKLTAAATAPQTKGNSSSGAANARQQTAATGNNGATVPAASLPPATKSK

169.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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