Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity).

Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.

479 amino acids

MESGSEEPDEQLLLLSEPALHAGPPAGRAAPGGAVRLRGEPGLEEEEEGEEDSGPEGDGEEEPLLRASGRGRRAGAARDKEPRVGAGHTGHAIDMNTFLDDPEFAEIITRAEQVIECGVLPERISQGSSGSYFVKDCKGKTIGVFKPKSEEPYGHLNPKWTKYFHKICCPCCFGRGCLVPNQGYLSEAGAYLVDDKLGLGVVPKTKVVWLVSETFNYSAIDRAKSRGKKYALEKVPKVAKKFNRIGLPPKVGSFQLFVEGYKEADYWLRKFETDPLPENTRKEFQSQFERLVILDYVIRNTDRGNDNWLVRYEKQDDGLNLSDKDIQWTVTEESTIKIAAIDNGLAFPFKHPDEWRAYPFHWAWLSQAQVPFSQETRDLVLPRISDMNFVQDLCEDLHELFKTDKGFDKATFENQMSVMRGQILNLTQALKDGKSPIQLVQMPRVIVERSSTGSQGRIVHLSNAFTQTFHSRKPFFSSW

53.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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