The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity). Involved in the control of flowering under long day conditions by promoting degradation of FTIP1 (PubMed:28254780). Recruits FTIP1 for degradation by the 26S proteasome in leaves, which affects RFT1 transport to the shoot apical meristem (SAM) (PubMed:28254780).

Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.

565 amino acids

MSSAGIATLSPLLDQFCFAPHGEPRLQQLDSIVIFLAMPGVAPMPMRVLHSDSVASVKLRIQQFKGFVTTKQRLVFSGHELSLNNSHVRDYGLTDGNVLHLVVRLADLRAISIETANGKKFQFQVESCCNVGYLKDKLSAESGQQLGSLKDQRLVFDGEELEDNQLIADISKKGAAVIHLFIRRPAKVQTQQGDKETVVTVVTPKDNDNLQTDALNLAKPAKGKPAPVEPIIANGKVKLSPAVMEMIYSTISGIENGYLPVMSTEGSGGVYFMKDSSGESNVAVFKPIDEEPMAKNNPRGLPLSTDGEGLKRGTRVGEGALREVAAYILDHPVYGCKSCDVPGFSGVPPTALVRCFHMGKGSNKVGSLQLFVDNNGSCEDMGPRAFPVKEVQKIAILDIRLANADRHAGNILVCQDGEDHLKLIPIDHGYCLPEKFEDCTFEWLYWPQAREPFGPETAAYIGSLDADKDIALLKFHGWALSPQCARVLRISTMLLKKGAERGLTPYDIGSILCRQTVKKESEIEAIIEEAEDAILPGTSEETFLETISEIMDFHLDKLAVKLKKF

61.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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