The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity). Undergoes autophosphorylation and phosphorylates serine/threonine residues of protein substrates. Phosphorylates RPN10 and UFD1 in vitro.

Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.

566 amino acids

MSSAGVALSPVRSEPLIMPLVRANSCLDSYPDDTIMIYLTLPGSVIPMRVLESDSIESVKLRIQSYRGFVVRNQKLVFGGRELARSNSNMRDYGVSEGNILHLVLKLSDLQVLDVKTTCGKHCRFHVERGRNIGYVKKQISKKRGDFVDPDEQEILYEGEKLEDQSLINDICRNDDSVLHLLVRRSAKVRVKPVEKNFELSIVAPQAKDKKGREAKSIVPPKKLSLEPVVVNSKAKVPLVVKDMIQSASDGLKSGNSPVRSSEGTGGAYFMQGPSGNKFVGVFKPIDEEPMAENNPQGLPLSPNGEGLKKGTKVGEGALREVAAYILDHPKSGNKSMFGEEIGFAGVPPTAMIECLHPGFNHPKGIKTKIGSLQMFTENDGSCEDMGPLSFPVEEVHKISVLDIRLANADRHGGNILMTKDESGKLVLVPIDHGYCLPESFEDCTFEWLYWPQARKPYSAETQEYIRSLDAEEDIDLLKFHGWKMPAETAQTLRISTMLLKKGVERGLTAFEIGTIMCRETLSKKSLVEEMVEEAQEAVLPGTSEAAFLEALSDVMDYHLDHSQEH

62.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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