Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).

Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.

838 amino acids

MATEIITEKKEIVARTRSSGITFNPPVTHDMVRSLFDPTIKKSFLECCITLTILANFVLCYYLINWFGLSQAKLIFLIQYVYWRLAYNLGIGIILHYQSHYESLTKYANQNKLFKKESAKTNWIASFFQFEIKSKMPNDYNLHSYPDELNCWLLFRQFVDLILMQDFTTYIIYVYLSLPTDVSSLINWKSLIGIAMILFNIWVKIDAHRVVKDYAWYWGDFFFLQDAELTFDGVFNISPHPMYSIGYLGYYGLSLICGDYRVLLVSVGGHFLQFLFLKYVESPHIERTYGSDSPSNSTQHQIDDLIAKENYDYSRPLINTGILFENFQFLRFSDYFTVSTILVLFSWFFTSKPSNNFLFVLTLLTKLTTWLLTSWILFQQSNRKWFTRLFLKNGYTQIYSYQQWQFLYNYSLIVTNTLLFLHTLSELYSIQSSDGLNNSHVIFGLLLCAIQIWCNVETRDAISDFGWFYGDFFLTNYITTRKLTSQGIYRYLNNPEAILGVAGIWGSVLMTNFSKTNVTLAVLWTVTNLIFVKLIEEPHVSKVYGNGTRVSGVQQTLLALKPFRWISDLIDDWGNKMMKSLHGFDSDSDSESISSGKKGNLSSLKLSKKSKLKNRVQSDNKLAPNSKFEIEDLEDEIVYLPNSVTISWKLPISMFNEKDWIGLYNVLETGSDRTQTKIPSLGHWSAVDATGYPHDSINTNSITEFKKGSKNVSGRVTFDANLLYFKPGIYEFRYHSKNSHKVLLISSPFQISFPEFDNEAQVDIKNEIMKFLDAISCMKNEKYFANDNKYFTADAFSNYIKDSFGIELSTDYIRRVNGDVEVISRRVHDIKEVLDSLN

97.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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