Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.

In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.

935 amino acids

MASLSSSFLVLFLLFQNSCYCFRSPLSVFKRYEESTRSLSNDCLGTTRPVMSPGSSDYTLDIRMPGVTPTESDTYLCKSYRLPVDDEAYVVDFRPHANMDTAHHMLLFGCNIPSSTDDYWDCSAGTCMDKSSIMYAWAKNAPPTKLPEGVGFRVGGKSGSRYFVLQVHYGNVKAFQDKHKDCTGVTVRVTPEKQPQIAGIYLSMSVDTVIPPGEEAVNSDIACLYNRPTIHPFAYRVHTHQLGQVVSGFRVRHGKWSLIGRQSPQLPQAFYPVEHPVEISPGDIIATRCLFTGKGRTSATYIGGTSNDEMCNLYIMYYMDAAHATSYMTCVQTGEPKLFQNIPEIANVPIPVSPDMMMMMGHGHHHTEAEPEKNTGLQQPKREEEEVLDQDVHLEEDTDWPGVNLKVGQVSGLALDPKNNLAIFHRGDHVWDENSFDRNFVYQQRGIGPIQESTILVVDPSSSKVLKSTGKNLFFLPHGLTIDRDGNYWVTDVALHQVFKLGAGKETPLLVLGRAFQPGSDRKHFCQPTDVAVDPITGNFFVADGYCNSRIMQFSPNGMFIMQWGEETSSNVPRPGQFRIPHSLTMVPDQGQLCVADRENGRIQCFHAETGNFVKQIKHQEFGREVFAVSYAPGGVLYAVNGKPYYGYSAPVQGFMLNFSNGDILDTFIPARKNFDMPHDIAAADDGTVYVGDAHANAVWKFSPSKAEHRSVKKAGIEVEEITETEIFETHIRSRPKTNESVEKQTQEKQQKQKNSAGVSTQEKQNVVQEINAGVPTQEKQNVVQESSAGVPTQEKQSVVQESSAGVSTQEKQSVVQESSAGVSFVLIITLLIIPIAVLIAIAIFIRWRKVRMYGGDIDHKSESSSVGILGKLRGKGSGGLNLGTFFATHKGYSRKGFDRLSTEGSDQEKDDDDGSDSEEEYSAPPIPPAPVSSS

103.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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