Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit pan2 to mRNA via its interaction with RNA and with pab1.

Belongs to the protein kinase superfamily. PAN3 family.

659 amino acids

MASAGKPALDDSRRGTGSPKMKARENAKDTLCRNVTIYGRCRYEDKGCAFNHDPLKVNSAYQFDSKKRFNVDSPSFTPSLLPSNGSSPTISSATMKKMATISPKAANAAPFQPRSVASRSNTSTPNSRQENINPDWTVAEVQEFVPQGFDVAHMTALQGNGNGTITPTNAFDPFVTASTPLSAGGAVGPVQPNPYSHDSAALGGAAFFPGSSGFQQPVQYHMYAPIGPHNQNTLGYQRNVHDLFLPNDFREELQKKAAATLQTLPNTQLPAQIDYFHSLVPLDLNHQKNATVFGFPSWVYKAQSSKDGNFYALRRLEGFRLTNEKAIRSVQAWKRVCNGSVVTIHDAFTSRSFQDSSLIFVTDYYPLSKTLAEQHLGTGQRFQGRHNVHIPEQVLWGYMTQIANALKAIHSNGLAARIIDASKILLTGKNRIRLNACAIMDVVQYDSQRTVADLQRQDLVNFGQLIVTLGANSPTVMHNPTKAMEHFTRAYSPQMKNSVFWLLNGLQKDQDRNIDIFITGISSQLMSTFDSALHLDDQLTSDLSRELENGRLVRLMTKLNLVNERPEYEHDRQWSENGERYFLKIFRDYVFHQVDAQGDAVVDLGHVLSCLNKLDAGSDEKITLVSRDEQSCFIVSYKELKKALESSFQALLKPARRMH

73.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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