Associates with IL31RA to form the IL31 receptor. Binds IL31 and activates STAT1, STAT3 and STAT5. Capable of transducing OSM-specific signaling events (By similarity). The OSM/OSM-R system is pivotal in the differentiation of oval cells into hepatocytes, thereby promoting liver regeneration.

Belongs to the type I cytokine receptor family. Type 2 subfamily.

962 amino acids

MAFSVVLHQVTFLLAVLSLRTSQSKVLGEPLQLTPEIHTVSLQSALQEANLEWTVPTFSHQELNIVFQIEISRMRTSNTIWVGNYSTTVKHEETVHWKWTSDIPLECATHFIRIRAMVDDAQYPPQSSWSNWSSWKEVNAQVSVPPDTLLIFPEDRLLEEGSNVTICLMIGQNLYNVSCKLQEEPIRGEQLDSHLSLIKLNNVVFLNNAGTNINCKAMNGTKNTFGTVLFVSKVLEEPKNFSCETRDFKTLNCLWEPGIDTTLSWHKQRSQHYTLYESFSGRREVSNHRNSHTWQITEDSQETYNFTLTAENNLRKRSVSISFNLTHRVHPKAPHDVTLKTVGATKAHMTWKVPSRGDYTLLCQVELQCEGEVIHEHNVSVHTSANYLFSDLEPDTEYKACVRCASANHFWKWSDWMQKKFRTPEAAPSEALDVWRDVRTENGRHVVTLFWKPLLKSQANGKIISYNIVVENEANPTESEQYSVRAPALGTNLSLDLHPYKIHISANNSAGASPESLVVLSSHSGHEEVHEKTIKGIKNGFNISWEPVSGDAIGYVVDWCAHSQTQRCDLQWKNVGPNITSTIITSDAFEPGVRYNFRIFERSVEENVRLVEKQRGYTQELAPSVNPGVTIHNLTPNSFSLKWQDYASDFQSGFIKGYLVYLKSKELQCNPNWERTVLSDKSVLCKYDVDDPETKTLTVENLRPESLYEFLVTPYTSAGQGPNETYTKVTTPDVRSHMLLQIILPMTLGVFLSIIVCYWKSQWVKEKCYPDIPNPYKSSILSLIKSKKNPHLIMNVKDCIPDVLEVINKAEGSKTQCVGSGKLHTEDVPTKPPLVPTEKDSSGPMPFVFLENFTYDQSAFDSGSHGFIPGPLKNTPHQLGLLAPPNKLQNVLENDYMKSLVESPTEETSLIYVSQLASPICGDKDSLVTNPPMPVHGSEYKKQMALPGSLTSASLKENNLTS

108.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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