Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the bicoumarin desertorin (PubMed:26389790). The non-reducing polyketide synthase desS first catalyzes the formation of the pentaketidic 4,7-dihydroxy-5-methylcoumarin from acetyl coenzyme A and 4 malonyl coenzyme A molecules (PubMed:26389790). Further O-methylation by desB leads to the formation of 7-demethylsiderin (PubMed:26389790). Then, an oxidative phenol coupling catalyzed by the cytochrome P450 monooxygenase desC forms the 6,8'-dimer M-desertorin A via dimerization the monomeric precursor, 7-demethylsiderin (PubMed:26389790). M-desertorin A is further converted to M-desertorin C (PubMed:26389790).

Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.

419 amino acids

MGTETEYLQSIQQALKSLTTAANNCQLTYTHAVGQDVHSLCAREAVRKTLVLEAYKFLQIAQGPVDAAVTCFEQTAHLASVRALLEAGVFEVLPTDGTPRTMKEVAEKLDVDESLLARLMRHASLYGPLEETGPGSYRHTPFSLVYLRPEIRGMVRFAMDEHMPAHLKLHEYLQQTSWTAPSSSTNNPYTHAHSITGTSMFANLSAPSNKHRLDAFNDAMTVQATTAIWMIDLFPFHEVLSPSASADTVLAVDIGGGTGRAISRIRSLAGNLPGRYILQDQAHVISNLPSPSPSSYLDGIETMTHDFFTPQPVAGAQIYLIRRCLHNWPEESVIRILRNIVPAMARTNSRLLIEEIIVPESNSGIEEGWMDMIMMALGAKQRTLEEWKGVLGTAGLEVVTVYRVDGICHGLIEARVKSE

46.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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