Protein O-glucosyltransferase. Catalyzes the reaction that attaches glucose through an O-glycosidic linkage to a conserved serine residue found in the consensus sequence C-X-S-X-[PA]-C in epidermal growth factor-like repeats. Regulates Notch signaling by glucosylating Notch in the ER, glucosylation is required for the correct folding and cleavage of Notch.

Belongs to the glycosyltransferase 90 family.

399 amino acids

MHFIIGIVICLSLSVIQSNTSDEGMCMAKEQCTDPEESTTGRSLYSADYNKYFNAIETALAGYVACNSTNCNCHADVLKADLKPFKAHGITKEMINRAKQYGTHYQVIGHKLYRQRECMFPARCSGVEHFVRPLLPLLPDMDLIVNCRDWPQIHRHWSKEKIPVLSFSKTAEYLDIMYPAWAFWEGGPAIALYPTGLGRWDLHRQTITKASADWEAKEPKAFFRGSRTSDERDALVLLSRAQPSLVDAQYTKNQAWKSPQDTLNAEPAREVTLEEHCRYRFLFNFRGVAASFRFKHLFLCRSLVFHVGDEWQEFFYPSLKPWVHYVPVPVRSTPEELEALITFFQEHDQLARAIAERGYEHIWNHLRMADVECYWKKLLKRYGKLIRYTVERDSTLIEV

46.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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