Catalyzes the iterative condensations of 8 molecules of malonyl-CoA to produce aromatic octaketides, SEK4 and SEK4b, the products of the minimal polyketide synthase for the benzoisochromanequinone actinorhodin. May be involved in the biosynthesis of the octaketide barbaloin.

Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.

403 amino acids

MGSLSNYSPVMEDVQAIRKAQKADGTATVMAIGTAHPPHIFPQDTYADFYFRATNSEHKVELKKKFDRICKKTMIGKRYFNYDEEFLKKYPNITSFDEPSLNDRQDICVPGVPALGAEAAVKAIAEWGRPKSEITHLVFCTSCGVDMPSADFQCAKLLGLRTNVNKYCVYMQGCYAGGTVMRYAKDLAENNRGARVLVVCAELTIIGLRGPNESHLDNAIGNSLFGDGAAALIVGSDPIIGVERPMFEIVCAKQTVIPNSEDVIHLHMREAGLMFYMSKDSPETISNNVEACLVDVFKSVGMTPPEDWNSLFWIPHPGGRAILDQVEARLKLRPEKFGATRTVLWDCGNMVSACVLYILDEMRRKSVADGLATYGEGLEWGVLLGFGPGMTVETILLHSLPPV

44.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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